May 20, 2003Circulation ResearchOpen Access

Matrix Metalloproteinase-3 Genotype Contributes to Age-Related Aortic Stiffening Through Modulation of Gene and Protein Expression

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Why the study?

Does the MMP-3 5A/6A promoter polymorphism contribute to age-related large artery stiffening in low cardiovascular risk individuals?

Population

203 low cardiovascular risk, unmedicated individuals, divided prospectively into two age groups. Additional…

Comparison

MMP-3 5A/6A promoter polymorphism homozygote… vs MMP-3 5A/6A promoter polymorphism heterozygote…

Design

Cross-sectional

Authors

TMTanya L. MedleyThe University of Melbourne BKBronwyn A. KingwellPreventive Cardiology CGChristoph D. GatzkaThe University of Melbourne

Discussion

Member takes

Implication

May link MMP-3 5A/6A homozygosity to higher aortic impedance in older low-risk adults; hypothesis-generating and requires longitudinal confirmation.

Structured PICO

Does the MMP-3 5A/6A promoter polymorphism contribute to age-related large artery stiffening in low cardiovascular risk individuals?

Population

203 low cardiovascular risk, unmedicated individuals (135 male), divided prospectively into two age groups (30 to 60 years, n=126; ≥61 years, n=77). Additional cohorts included 40 randomly selected older men for dermal biopsies and 7 postmortem aortic samples.

Intervention

MMP-3 5A/6A promoter polymorphism homozygote genotype (5A/5A or 6A/6A)

Comparator

MMP-3 5A/6A promoter polymorphism heterozygote genotype (5A/6A)

Outcome

Noninvasive large artery stiffness measured as ascending aortic input impedance and characteristic impedancesurrogate

The MMP-3 5A/6A genotype is associated with age-related large artery stiffening, suggesting heterozygotes maintain an optimal balance of vascular matrix remodeling.

Cite This Study

Medley et al. (2003) studied this question.

synapsesocial.com/papers/6a72dc8bbeb211e5dcf3cf1f https://doi.org/10.1161/01.res.0000076891.24317.ca

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Implication

May link MMP-3 5A/6A homozygosity to higher aortic impedance in older low-risk adults; hypothesis-generating and requires longitudinal confirmation.

Matrix Metalloproteinase-3 Genotype Contributes to Age-Related Aortic Stiffening Through Modulation of Gene and Protein Expression

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Matrix Metalloproteinase-3 Genotype Contributes to Age-Related Aortic Stiffening Through Modulation of Gene and Protein Expression

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider