Key result
Stromelysin-1 5A/5A genotype linked to ~4 mmHg higher SBP versus other genotypes.
Why the study?
Is the stromelysin-1 5A/5A genotype associated with higher blood pressure in a community population?
Population
1111 randomly selected male and female community subjects (27-77 years)
Comparison
Stromelysin-1 (MMP-3) 5A/5A genotype vs Stromelysin-1 (MMP-3) 5A/6A and 6A/6A genotypes
Design
Cross-sectional
Authors
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Should not change BP management; hypothesis-generating for stromelysin-1 genotype in hypertension and requires prospective validation.
Cross-Sectional (n=1,111)
Is the stromelysin-1 5A/5A genotype associated with higher blood pressure in a community population?
Mean Difference: 4.2
The stromelysin-1 5A/5A genotype is independently associated with higher systolic and diastolic blood pressure in a general community population.
Beilby et al. (2005) conducted a cross-sectional in Blood pressure (n=1,111). Stromelysin-1 5A/5A genotype vs. 5A/6A and 6A/6A genotypes was evaluated on Systolic blood pressure (SBP) and diastolic blood pressure (DBP) (MD +4.2 mmHg (SBP) and +2.2 mmHg (DBP)). The stromelysin-1 5A/5A genotype was associated with higher mean systolic (+4.2 mmHg) and diastolic (+2.2 mmHg) blood pressure compared to 5A/6A and 6A/6A genotypes.
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