Circulating microparticles were the strongest predictors of high SYNTAX II scores (AUC 0.856), highlighting their potential as biomarkers for early detection and risk stratification of CAD.
Case-Control (n=120)
Open-label
No
Do circulating microparticles correlate with coronary artery disease severity as defined by the SYNTAX Score II in patients with angiographically confirmed CAD?
Circulating microparticles are strong predictors of coronary artery disease severity and may serve as useful biomarkers for early detection and risk stratification.
Effect estimate: AUC 0.856
OBJECTIVE: Immune-inflammatory processes play a central role in the progression of atherosclerosis. The objective of this study is to evaluate whether circulating microparticles (MPs) correlate with coronary artery disease (CAD) severity defined by SYNTAX Score II in patients aged 45 years. METHODS: This single-centre, open-label, comparative study enrolled 80 patients with angiographically confirmed CAD (40 aged 45 years) between June 2023 and July 2024. Forty age- and sex-matched individuals with angiographically normal coronary arteries served as the control group. Blood samples were analysed for total MPs, endothelial MPs, platelet-derived MPs, and leukocyte markers (CD45, CD19, CD3, CD16). RESULTS: microparticles (AUC 0.856) were the strongest predictors of high SYNTAX II scores. CONCLUSIONS: Our study highlights the potential of MPs as biomarkers for early detection and risk stratification of CAD, supporting more personalised and effective treatment strategies.
Mahapatra et al. (2026) conducted a case-control in Coronary artery disease (n=120). Circulating microparticles vs. Angiographically normal coronary arteries was evaluated on High SYNTAX II scores (AUC 0.856). Circulating microparticles were the strongest predictors of high SYNTAX II scores (AUC 0.856), highlighting their potential as biomarkers for early detection and risk stratification of CAD.