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December 16, 2019Current Medicinal Chemistry

Cell-Derived Microparticles and Acute Coronary Syndromes: Is there a Predictive Role for Microparticles?

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Key result

Cell-derived microparticles, particularly endothelial MPs, show promise as circulating biomarkers for predicting future adverse cardiovascular events in patients with acute coronary syndromes.

Why the study?

Patients with ACS remain at increased risk for adverse cardiovascular events and their prognosis is difficult to determine, prompting an evaluation of the predictive role of cell-derived microparticles.

Do cell-derived microparticles predict future adverse cardiovascular events in patients with acute coronary syndromes?

Population

Patients with ACS

Design

Review

Authors

EZEffimia ZachariaUniversity of MinnesotaKZKonstantinos ZachariasAristotle University of ThessalonikiGPGeorge-Angelo PapamikroulisNational and Kapodistrian University of Athens

Discussion

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Member takes

Overview

Should not yet alter ACS risk assessment; leaves open endothelial microparticles' utility as biomarkers pending validation.

Structured PICO

Do cell-derived microparticles predict future adverse cardiovascular events in patients with acute coronary syndromes?

P
Population
Patients with Acute Coronary Syndromes (ACS)
I
Intervention
Cell-derived Microparticles (MPs) as predictive biomarkers
O
Outcome
Predictive role for future adverse cardiovascular eventssurrogate

Cell-derived microparticles, particularly endothelial MPs, hold promise as potential circulating biomarkers for predicting adverse cardiovascular events in patients with acute coronary syndromes, though large-scale studies are needed.

Limitations

  • Large-scale clinical studies are required to evaluate whether the measurement of plasma MPs could be of clinical significance
  • Large-scale clinical studies are required to evaluate clinical significance

Cite This Study

Zacharia et al. (2019) conducted a review in Acute Coronary Syndromes. Cell-derived Microparticles (MPs) was evaluated on Predictive role of MPs for future adverse cardiovascular events. Cell-derived microparticles, particularly endothelial MPs, show promise as circulating biomarkers for predicting future adverse cardiovascular events in patients with acute coronary syndromes.

synapsesocial.com/papers/6a15423b5347fbb1739f7cb2https://doi.org/10.2174/0929867327666191213104841
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet Function in Acute Myocardial Infarction Treated With Direct Angioplasty1996 · 303 citations
  2. 2Platelet-, monocyte-derived and tissue factor-carrying circulating microparticles are related to acute myocardial infarction severity2017 · 99 citations
  3. 3Association between platelet reactivity and circulating platelet-derived microvesicles in patients with acute coronary syndrome2014 · 33 citations
  4. 4Circulating Microparticles Carry a Functional Endothelial Nitric Oxide Synthase That Is Decreased in Patients With Endothelial Dysfunction2013 · 68 citations
  5. 5Platelet microparticles and calcium homeostasis in acute coronary ischemias1997 · 103 citations