Key result
BMI linked to a U-shaped PAD risk in hypertensives with lowest risk at ~26 kg/m2.
Why the study?
High BMI is a recognized cardiovascular risk factor, but its role in peripheral artery disease remains perplexing.
Is Body Mass Index associated with the risk of peripheral artery disease in a Chinese hypertensive population?
Cross-Sectional (n=10,896)
Is Body Mass Index associated with the risk of peripheral artery disease in a Chinese hypertensive population?
In a Chinese hypertensive population, BMI demonstrates a U-shaped association with the risk of peripheral artery disease, with the lowest risk observed at a BMI of 25.7 kg/m2.
Answers are grounded in this paper and cite their sources.
May inform BMI targets in Chinese hypertensives; leaves open causality and optimal thresholds pending prospective studies.
Abstract Background: High body mass index (BMI) is a well-recognized risk factor of cardiovascular diseases. But its role in peripheral artery disease (PAD) remains perplexing. Our study evaluated the association of BMI with PAD in Chinese hypertensive population. Methods: This is a cross-sectional study with enrollment data from the Chinese H-type Hypertension Registry.10896 hypertensive patients aged ≥18 years were included in the final analysis. Results: The prevalence of PAD diagnosed by ABI in this study was 3.2% (n=351). A U-shaped relationship between BMI and PAD was found. Per SD increment (3.6 kg/m²) on the left side of the BMI threshold (BMI < 25.7 kg/m²) was associated with a 27% decreased in the adjusted risk of PAD [OR, 0.73; 95% confidence interval (CI) 0.60, 0.89; P=0.002]; BMI was significantly positively associated with the risk of PAD (OR, 1.52; 95% CI 1.52, 1.93; P=0.001) in those with BMI ≥25.7 kg/m². Conclusion: A “U-shaped” relationship between BMI and the risk of PAD in Chinese hypertensive population was found. BMI with the lowest risk of PAD was estimated to be 25.7 kg/m².
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Li et al. (2020) conducted a cross-sectional in Hypertension (n=10,896). Body mass index (BMI) was evaluated on Peripheral arterial disease (ABI ≤ 0.9) (OR 0.73, 95% CI 0.60-0.89, p=0.002). Body mass index demonstrated a U-shaped association with the risk of peripheral arterial disease in Chinese hypertensive patients, with the lowest risk observed at a BMI of 25.7 kg/m2.
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