Key result
Clevidipine, nicardipine, labetalol, esmolol, and fenoldopam are preferred choices for managing hypertensive crises in the elderly, whereas nitroprusside, hydralazine, and nifedipine should be avoided.
Why the study?
What are the preferred pharmacological options for managing hypertensive crises in elderly patients?
What are the preferred pharmacological options for managing hypertensive crises in elderly patients?
This review highlights preferred and avoided pharmacological agents for managing hypertensive crises in elderly patients based on efficacy, tolerability, and risk of complications.
May guide agent selection in elderly hypertensive crises; leaves open need for RCTs to confirm preferences.
Hypertensive crises are elevations of blood pressure higher than 180/120 mmHg. These can be urgent or emergent, depending on the presence of end organ damage. The clinical presentation of hypertensive crises is quite variable in elderly patients, and clinicians must be suspicious of non-specific symptoms. Managing hypertensive crises in elderly patients needs meticulous knowledge of the pathophysiological changes in them, pharmacological options, pharmacokinetics of the medications used, their side effects, and their interactions with other medications. Clevidipine, nicardipine, labetalol, esmolol, and fenoldopam are among the preferred choices in the elderly due to their efficacy and tolerability. Nitroprusside, hydralazine, and nifedipine should be avoided, unless there are no other options available, due to the high risk of complications and unpredictable responses.
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Alshami et al. (2018) conducted a review in Hypertensive crises. Antihypertensive agents (clevidipine, nicardipine, labetalol, esmolol, fenoldopam) was evaluated. Clevidipine, nicardipine, labetalol, esmolol, and fenoldopam are preferred choices for managing hypertensive crises in the elderly, whereas nitroprusside, hydralazine, and nifedipine should be avoided.
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