April 1, 1993HeartOpen Access

Double blind controlled study of low dose intravenous perindoprilat or enalaprilat infusion in elderly patients with heart failure.

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Why the study?

Does low dose intravenous perindoprilat or enalaprilat infusion safely lower blood pressure in elderly patients with heart failure?

Population

36 unselected elderly patients with symptomatic but stable chronic cardiac failure admitted for supervised…

Comparison

Enalaprilat or perindoprilat by constant rate… vs Intravenous placebo by constant rate intravenous…

Design

RCT, randomly allocated, Double blind, placebo controlled

Follow-up

6 hours

Authors

RMRobert J. MacFadyenApple (Israel)KLKennedy R. LeesUniversité Claude Bernard Lyon 1 JRJL ReidThe University of Sydney

Discussion

Member takes

Implication

IV diacid ACE inhibitors lower BP in elderly HF but require early termination in 5/12 cases; cautions use and leaves optimal dosing open for trials.

Structured PICO

Does low dose intravenous perindoprilat or enalaprilat infusion safely lower blood pressure in elderly patients with heart failure?

Population

36 unselected elderly (aged 60-87 years) patients with symptomatic but stable chronic cardiac failure (New York Heart Association grades II-IV) admitted for supervised diuretic withdrawal.

Intervention

Enalaprilat (1.5 mg over six hours) or perindoprilat (1 mg over six hours) by constant rate intravenous infusion (5 ml/hour).

Comparator

Intravenous placebo (saline) by constant rate intravenous infusion (5 ml/hour).

Outcome

Blood pressure and heart rate responses, drug concentration, plasma renin, and ACE activities.surrogate

Slow intravenous infusion of diacid ACE inhibitors (perindoprilat and enalaprilat) safely lowers blood pressure in elderly patients with heart failure, with similar hemodynamic effects between the two drugs.

Cite This Study

MacFadyen et al. (1993) studied this question.

synapsesocial.com/papers/6a8fb4734a3389b78e830677 https://doi.org/10.1136/hrt.69.4.293

Topics

Heart failure HFrEF treatment

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Implication

IV diacid ACE inhibitors lower BP in elderly HF but require early termination in 5/12 cases; cautions use and leaves optimal dosing open for trials.

Double blind controlled study of low dose intravenous perindoprilat or enalaprilat infusion in elderly patients with heart failure.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Double blind controlled study of low dose intravenous perindoprilat or enalaprilat infusion in elderly patients with heart failure.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider