Key result
A single 2.0 mg dose of perindopril caused a less pronounced maximum drop in blood pressure and a significantly lower incidence of asymptomatic hypotension compared to 2.5 mg of enalapril.
Why the study?
Does a single dose of perindopril 2.0 mg cause less first-dose hypotension compared to enalapril 2.5 mg in patients with chronic heart failure initiating ACE inhibitor therapy?
Population
298 patients >18 years old with stable symptomatic chronic heart failure due to ischemic heart disease or…
Comparison
Perindopril 2.0 mg single dose vs Enalapril 2.5 mg single dose
Design
RCT, randomised, Single blind
Follow-up
at least 10 hours
Authors
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Supports selecting perindopril over enalapril to minimize first-dose hypotension when starting ACE inhibitor therapy in chronic HF; extends head-to-head tolerability evidence.
RCT (n=298)
Single blind
parallel
Yes
Does a single dose of perindopril 2.0 mg cause less first-dose hypotension compared to enalapril 2.5 mg in patients with chronic heart failure initiating ACE inhibitor therapy?
Initiation of ACE inhibitor therapy with low-dose perindopril causes less first-dose hypotension than low-dose enalapril in patients with chronic heart failure.
Vítovec et al. (2000) conducted an RCT in chronic heart failure (n=298). Perindopril vs. Enalapril 2.5 mg was evaluated on First-dose hypotension (maximum drop in blood pressure and incidence of asymptomatic hypotension). A single 2.0 mg dose of perindopril caused a less pronounced maximum drop in blood pressure and a significantly lower incidence of asymptomatic hypotension compared to 2.5 mg of enalapril.
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