Why the study?
Does intravenous perindoprilat alter blood pressure and what are its pharmacokinetics in normotensive male volunteers?
Population
8 normotensive salt replete male volunteers
Comparison
Perindoprilat 1 mg intravenous constant rate… vs Saline placebo intravenous infusion over 3 h
Design
RCT, randomised, single (subject) blinded
Authors
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Slower infusions lower peak ACE inhibition during BP reduction; extends pharmacokinetic data supporting individualized IV perindoprilat titration in patients.
Does intravenous perindoprilat alter blood pressure and what are its pharmacokinetics in normotensive male volunteers?
Low dose constant rate infusions of perindoprilat show a sigmoid drug accumulation profile and may allow for individual dose titration in patients.
MacFadyen et al. (1992) studied this question.
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