Why the study?
Does intravenous perindoprilat reduce blood pressure in normotensive volunteers with salt depletion or salt repletion?
Population
12 normotensive male volunteers, aged 19-28 years, weighing 53-77 kg, undergoing salt depletion or salt…
Comparison
Intravenous perindoprilat 0.67 mg infused over 4… vs Matching placebo infused over 4 hours.
Design
RCT, double-blind
Follow-up
4 hours
Authors
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IV perindoprilat lowers supine SBP independent of renin activation; confirms ACEI efficacy across salt states in normotensives.
Does intravenous perindoprilat reduce blood pressure in normotensive volunteers with salt depletion or salt repletion?
Intravenous perindoprilat significantly reduces supine systolic blood pressure in normotensive volunteers, independent of renin system activation via salt depletion.
MacFadyen et al. (1994) studied this question.
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