Key result
Peak oxygen uptake (VO2) independently predicted outcomes (57 deaths, 149 cardiovascular events) in 284 heart transplant candidates, outperforming submaximal respiratory slopes.
Why the study?
Does peak VO2 better predict outcomes than submaximal respiratory slopes in adult heart transplant candidates?
Cohort (n=284)
Does peak VO2 better predict outcomes than submaximal respiratory slopes in adult heart transplant candidates?
Peak VO2 is a superior independent predictor of outcomes compared to submaximal respiratory data in heart transplant candidates, though submaximal data may be useful when maximal exercise is contraindicated.
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Supports peak VO2 for risk stratification in transplant candidates; extends HF prognostic data but remains hypothesis-generating pending prospective validation.
Pardaens et al. (2000) conducted a cohort in Chronic heart failure in heart transplant candidates (n=284). Peak oxygen uptake (VO2) vs. Submaximal respiratory slopes was evaluated on Death or cardiovascular events. Peak oxygen uptake (VO2) independently predicted outcomes (57 deaths, 149 cardiovascular events) in 284 heart transplant candidates, outperforming submaximal respiratory slopes.
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