Propargyl Uridine-Based Synthesis of Glycosylated RNA Analogues

Jia-Yan Wei; Bo-Xu Gai; Chuan-Shuo Wu; Li Liu; Liang Cheng

doi:10.1039/d6ob00597g

January 1, 2026Organic & Biomolecular Chemistry

Propargyl Uridine-Based Synthesis of Glycosylated RNA Analogues

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Key Points

The study aims to develop a method for synthesizing glycosylated RNA analogues using click chemistry.
Utilized a click chemistry strategy for synthesis.
Employed β-D-glucopyranosyl azide for site-selective glycosylation.
Focused on N3-propargyl and 2′-O-propargyl uridines for generating the analogues.
Successfully synthesized N3-triazole- and 2′-O-triazole-substituted glycosylated uridines.
Demonstrated effective incorporation of glycosylated units into RNA oligonucleotides.

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Abstract

We report a click chemistry strategy for synthesizing N3-triazole- and 2′-O-triazole-substituted glycosylated uridines and RNA oligonucleotides from N3-propargyl and 2′-O-propargyl uridines. Using β-D-glucopyranosyl azide, site-selective glycosylation was achieved at nucleoside...

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Cite This Study

Wei et al. (2026) studied this question.

synapsesocial.com/papers/6a17dc853fad632b0f9d937b https://doi.org/10.1039/d6ob00597g

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Propargyl Uridine-Based Synthesis of Glycosylated RNA Analogues

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Abstract

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Cite This Study

Propargyl Uridine-Based Synthesis of Glycosylated RNA Analogues

Key Points

Ask about this paper

Abstract

Discussion

Cite This Study

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