What does this research mean for the field?

Delayed breast reconstruction following postmastectomy radiation therapy (PMRT) is associated with lower postoperative complications and better cosmetic outcomes compared to immediate reconstruction, despite similar overall flap survival. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The analysis aims to evaluate the impact of postmastectomy radiation therapy on flap outcomes in breast reconstruction.

May 28, 2026Plastic & Reconstructive Surgery Global OpenOpen Access

Postmastectomy Radiation Therapy on Flap Outcomes in Breast Reconstruction: A Systematic Review and Meta-analysis

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The analysis aims to evaluate the impact of postmastectomy radiation therapy on flap outcomes in breast reconstruction.
Systematic review and meta-analysis following PRISMA guidelines
Search conducted on PubMed and Cochrane Library (2000-2024)
Inclusion criteria focused on comparing flap outcomes between irradiated and nonirradiated groups.
Higher complication rates observed in irradiated flaps for immediate reconstruction, particularly fat necrosis and flap contracture.
Delayed reconstruction after PMRT showed fewer complications and better aesthetic outcomes.
Subgroup analysis indicated lower fat necrosis rates in deep inferior epigastric perforator flaps compared to other flaps.

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Implication

Systematic review and meta-analysis reveal complications in immediate reconstruction due to radiation therapy, suggesting improved outcomes with delayed procedures.

Cite This Study

Alameri et al. (2026) studied this question.

synapsesocial.com/papers/6a17dcbb3fad632b0f9d95dc https://doi.org/10.1097/gox.0000000000007776

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Implication

Systematic review and meta-analysis reveal complications in immediate reconstruction due to radiation therapy, suggesting improved outcomes with delayed procedures.

Postmastectomy Radiation Therapy on Flap Outcomes in Breast Reconstruction: A Systematic Review and Meta-analysis

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Discussion

Implication

Cite This Study

Postmastectomy Radiation Therapy on Flap Outcomes in Breast Reconstruction: A Systematic Review and Meta-analysis

Key Points

Discussion

Implication

Cite This Study

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