Key result
The ACE-DD genotype was associated with a significant reduction in the echocardiographic E/A ratio after 6 years (p=0.0001), indicating deteriorating myocardial diastolic properties.
Why the study?
Does the ACE-DD genotype affect diastolic function in healthy subjects over 6 years?
Cohort (n=275)
Does the ACE-DD genotype affect diastolic function in healthy subjects over 6 years?
The ACE-DD genotype is associated with a significant deterioration in myocardial diastolic properties over 6 years in healthy subjects.
Answers are grounded in this paper and cite their sources.
ACE-DD may flag higher risk for diastolic decline in healthy adults; leaves open its value for risk stratification or prevention trials.
BACKGROUND: The ACE-D allele has been associated with cardiovascular disease. The study evaluates the relationship between the ACE-ID genotypes and diastolic function in healthy subjects after 6 years of follow-up. METHODS: Two hundred and seventy-five healthy volunteers aged 25-55 years had normal physical examination, 12-lead ECG, acceptable echocardiographic windows and echocardiogram at entry. Venous blood was drawn for DNA analysis. RESULTS: Two hundred and forty-two subjects completed 6 years of follow-up. Three genetically distinct groups were obtained: ACE-DD group (n=71, 26F/45M, mean age 48 +/- 7 years); ACE-ID (n=115, 39F/76M, mean age 40 +/- 7 years); and ACE-II (n=56, 20F/36M, mean age 47 +/- 6 years). Significant differences in E/A ratio were found between ACE-DD and ACE-ID, and ACE II (p=0.028, <0.0001, 0.0001), respectively. After 6 years, echocardiography showed a significant reduction of E/A ratio in the ACE-DD group, p=0.0001. CONCLUSION: The data suggest that ACE-DD is associated with deteriorating myocardial diastolic properties.
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Pasquale et al. (2004) conducted a cohort in Healthy subjects (n=275). ACE-DD genotype vs. ACE-ID and ACE-II genotypes was evaluated on E/A ratio (p=0.0001). The ACE-DD genotype was associated with a significant reduction in the echocardiographic E/A ratio after 6 years (p=0.0001), indicating deteriorating myocardial diastolic properties.
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