Why the study?
Does the ACE I/D gene polymorphism influence left ventricular diastolic filling abnormalities in patients with essential hypertension?
Does the ACE I/D gene polymorphism influence left ventricular diastolic filling abnormalities in patients with essential hypertension?
The ACE I/D gene polymorphism, particularly the DD genotype, modulates the relationship between left ventricular mass and diastolic filling abnormalities in patients with essential hypertension.
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ACE DD genotype may link LV mass to diastolic filling in hypertension; hypothesis-generating and requires prospective validation before clinical use.
Clarkson et al. (1997) studied this question.
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