Key result
The ACE gene D allele was significantly associated with left ventricular hypertrophy in patients with hypertension and HFpEF (additive model OR 0.53; 95% CI 0.34-0.84; p=0.005).
Why the study?
Is the ACE gene D allele associated with left ventricular hypertrophy in hypertensive patients with HFpEF?
Population
176 patients with hypertension and HFpEF. Excluded: significant coronary, valvular, pericardial and…
Comparison
ACE gene D allele (I/D polymorphism) vs Absence of ACE gene D allele / I allele
Design
Case-control
Authors
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Hypothesis-generating for ACE genotyping in hypertensive HFpEF; prospective studies needed before clinical consideration.
Case-Control (n=176)
No
Is the ACE gene D allele associated with left ventricular hypertrophy in hypertensive patients with HFpEF?
Odds Ratio: 0.53 (95% CI 0.34–0.84)
p-value: p=0.005
The ACE gene D allele is significantly associated with the development of left ventricular hypertrophy in hypertensive patients with HFpEF.
Bahramali et al. (2016) conducted a case-control in Hypertension with heart failure with preserved ejection fraction (HFpEF) (n=176). ACE gene D allele vs. Non-D allele genotypes was evaluated on Left ventricular hypertrophy (LVH) (OR 0.53, 95% CI 0.34-0.84, p=0.005). The ACE gene D allele was significantly associated with left ventricular hypertrophy in patients with hypertension and HFpEF (additive model OR 0.53; 95% CI 0.34-0.84; p=0.005).
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