Why the study?
Is the ACE gene I/D polymorphism associated with chronic heart failure susceptibility and severity in Chinese Han patients?
Is the ACE gene I/D polymorphism associated with chronic heart failure susceptibility and severity in Chinese Han patients?
In Chinese Han patients with CHF, the ACE gene DD polymorphism is associated with more severe disease, characterized by greater left ventricular dilation and higher renin-angiotensin system activation.
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ACE DD may flag higher-risk Chinese Han CHF; leaves open whether genotyping informs stratification or therapy selection.
Huang et al. (2004) studied this question.
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