Why the study?
Is the ACE gene I/D polymorphism associated with essential hypertension in a Chinese population?
Population
272 subjects from a Chinese population, comprising 157 hypertensive and 115 normotensive subjects
Comparison
Angiotensin converting enzyme gene… vs Normotensive subjects (case-control comparison)
Design
Case-control
Authors
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Should not guide hypertension risk assessment or screening; leaves open ethnic-specific genetic associations in larger cohorts.
Is the ACE gene I/D polymorphism associated with essential hypertension in a Chinese population?
The ACE gene I/D polymorphism is not associated with essential hypertension in this Chinese population, although it determines plasma ACE activity in normotensives.
Fu‐Tien Chiang (1997) studied this question.
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