Key result
Enalapril induced significantly greater regression of left ventricular hypertrophy and improvement in diastolic filling in hypertensive patients with the DD genotype compared to ID or II genotypes.
Why the study?
Does the ACE gene polymorphism affect the efficacy of enalapril in reducing left ventricular hypertrophy and improving diastolic filling in patients with essential hypertension?
Cohort (n=60)
Does the ACE gene polymorphism affect the efficacy of enalapril in reducing left ventricular hypertrophy and improving diastolic filling in patients with essential hypertension?
Enalapril-induced regression of left ventricular hypertrophy and improvement in diastolic filling are significantly greater in hypertensive patients with the DD genotype of the ACE gene.
No takes yet. Share an insight, caveat, or question.
Supports ACE genotype influencing enalapril response on LVH; hypothesis-generating and should not yet change practice.
Sasaki et al. (1996) conducted a cohort in essential hypertension (n=60). Enalapril vs. Baseline / ID and II genotypes was evaluated on Changes in left ventricular mass index and atrial systolic velocity:early diastolic velocity ratio. Enalapril induced significantly greater regression of left ventricular hypertrophy and improvement in diastolic filling in hypertensive patients with the DD genotype compared to ID or II genotypes.
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