Key result
A single 10 mg dose of enalapril produced a significantly larger absolute fall in serum ACE activity in men with the DD genotype compared to the II genotype (difference at 4h: 10.7; 95% CI 3.8-17.6).
Why the study?
Does ACE genotype influence changes in blood pressure and serum ACE activity after a single dose of enalapril in healthy men?
Population
27 healthy men, n=9 each of ACE genotype DD, ID, and II
Comparison
Single oral dose of enalapril 10 mg vs Comparison between ACE genotypes (DD, ID, II)
Design
Cohort
Follow-up
24 hours
Authors
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Genotype affects ACE activity reduction after enalapril but not BP response in healthy men; leaves open personalized dosing utility pending outcome trials.
Does ACE genotype influence changes in blood pressure and serum ACE activity after a single dose of enalapril in healthy men?
Mean Difference: 10.7 (95% CI 3.8–17.6)
ACE genotype influences the absolute reduction in serum ACE activity after enalapril administration but does not significantly affect the blood pressure response in healthy men.
Todd et al. (1995) studied Healthy (n=27). Enalapril vs. ACE genotype II (compared to DD) was evaluated on Absolute fall in serum ACE activity at 4 hours (MD 10.7 nmol ml-1 min-1, 95% CI 3.8-17.6). A single 10 mg dose of enalapril produced a significantly larger absolute fall in serum ACE activity in men with the DD genotype compared to the II genotype (difference at 4h: 10.7; 95% CI 3.8-17.6).
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