What does this research mean for the field?

The magnitude and duration of the physiological response to the ACE inhibitor enalaprilat are significantly greater in individuals homozygous for the II ACE genotype compared to the DD genotype, with genotype and plasma angiotensin II levels predicting over 50% of the variation in response. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 17, 1998CirculationOpen Access

ACE (I/D) Genotype as a Predictor of the Magnitude and Duration of the Response to an ACE Inhibitor Drug (Enalaprilat) in Humans

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Why the study?

Does ACE (I/D) genotype predict the magnitude and duration of the blood pressure response to intravenous enalaprilat in normotensive men?

Structured PICO

Does ACE (I/D) genotype predict the magnitude and duration of the blood pressure response to intravenous enalaprilat in normotensive men?

Population

23 normotensive men with DD (n=12) and II (n=11) ACE genotypes

Intervention

Intravenous infusion of enalaprilat

Comparator

Intravenous infusion of placebo

Outcome

Dose ratio (DR) of PD20 (dose of angiotensin I required to raise mean blood pressure by 20 mm Hg) during enalaprilat to that during placebo at 1 and 10 hours after dosingsurrogate

The magnitude and duration of the blood pressure response to the ACE inhibitor enalaprilat are significantly greater in normotensive men homozygous for the II ACE genotype compared to the DD genotype.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Does not support genotype-guided dosing in normotensives; leaves open whether ACE I/D polymorphism predicts response in hypertensive patients.

Cite This Study

Ueda et al. (1998) studied this question.

synapsesocial.com/papers/6a1bc39c412da96b219cc526 https://doi.org/10.1161/01.cir.98.20.2148

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Implication

Does not support genotype-guided dosing in normotensives; leaves open whether ACE I/D polymorphism predicts response in hypertensive patients.

ACE (I/D) Genotype as a Predictor of the Magnitude and Duration of the Response to an ACE Inhibitor Drug (Enalaprilat) in Humans

Structured PICO

Discussion

Implication

Cite This Study

ACE (I/D) Genotype as a Predictor of the Magnitude and Duration of the Response to an ACE Inhibitor Drug (Enalaprilat) in Humans

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider