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June 1, 1995Hypertension

Enhanced Pressor Response to Angiotensin I in Normotensive Men With the Deletion Genotype (DD) for Angiotensin-Converting Enzyme

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Why the study?

Does the ACE DD genotype increase pressor responsiveness to Ang I compared to the II genotype in normotensive men?

Population

20 normotensive men

Comparison

Stepwise infusions of incremental doses of… vs Comparison between DD genotype and II genotype…

Design

Cross-sectional

Authors

SUShinichiro UedaGeneral / Preventive / LipidsHEHenry L. ElliottUniversity of StrathclydeJMJames J. MortonWestern Infirmary

Discussion

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Implication

Supports mechanistic link of ACE DD genotype to Ang I responsiveness in normotensives; leaves open clinical relevance and needs prospective validation.

Structured PICO

Does the ACE DD genotype increase pressor responsiveness to Ang I compared to the II genotype in normotensive men?

P
Population
20 normotensive men (10 with the DD genotype and 10 with the II genotype for the angiotensin-converting enzyme gene)
I
Intervention
Stepwise infusions of incremental doses of angiotensin I (Ang I) and Ang II
C
Comparator
Comparison between DD genotype and II genotype subjects
O
Outcome
Pressor responses expressed as PD20 (angiotensin dose required to raise mean blood pressure by 20 mm Hg) and Ang II production during Ang I infusionsurrogate

Normotensive men with the ACE DD genotype exhibit increased pressor responsiveness to Ang I due to higher Ang II generation, providing a mechanistic rationale for its association with cardiovascular disease.

Cite This Study

Ueda et al. (1995) studied this question.

synapsesocial.com/papers/6a7047d4e71d69abee088160https://doi.org/10.1161/01.hyp.25.6.1266
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Polymorphisms of the angiotensin-converting-enzyme gene in subjects who die from coronary heart disease1994 · 216 citations
  2. 2A pragmatic approach to the pressor dose‐response as an index of vascular reactivity and adrenoceptor function in man.1987 · 28 citations
  3. 3Measurement of plasma angiotensin II1985 · 109 citations
  4. 4The angiotensin I converting enzyme gene and predisposition to high blood pressure.1993 · 233 citations
  5. 5PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1)1992 · 1,249 citations