Key result
Losartan and ramiprilat significantly reduced myocardial infarct size compared to saline (e.g., 25.3% for 10-week losartan vs 48.3% for saline, p<0.001) in a rat model of ischemia/reperfusion.
Why the study?
Does ramiprilat or losartan reduce myocardial infarct size and arrhythmias during ischemia/reperfusion in rat hearts?
Population
Rats undergoing 30 min of left anterior descending artery occlusion and subsequent reperfusion for 120 min
Comparison
Losartan 10 mg/kg per day for 1, 4, or 10 weeks… vs Saline
Design
Preclinical
Follow-up
120 min reperfusion
Authors
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Should not change clinical practice in MI; hypothesis-generating for RAS inhibitor cardioprotection in ischemia/reperfusion.
Does ramiprilat or losartan reduce myocardial infarct size and arrhythmias during ischemia/reperfusion in rat hearts?
Absolute Event Rate: 25.3% vs 48.3%
p-value: p=<0.001
Losartan and ramiprilat protect the rat heart against ischemia/reperfusion injury independently of their hemodynamic effects but in a time-dependent manner.
Safari et al. (2011) studied Myocardial ischemia/reperfusion injury. Ramiprilat and losartan vs. Saline was evaluated on Myocardial infarct size (p=<0.001). Losartan and ramiprilat significantly reduced myocardial infarct size compared to saline (e.g., 25.3% for 10-week losartan vs 48.3% for saline, p<0.001) in a rat model of ischemia/reperfusion.
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