Key result
Atrial secondary tricuspid regurgitation predominates in women, while ventricular etiology is more common in men.
Why the study?
While tricuspid regurgitation typically affects more women, the impact of biological sex on etiology and post-treatment outcomes has not been conclusively established.
This review highlights important sex-specific differences in the anatomy, etiology, and treatment outcomes of tricuspid regurgitation, emphasizing the need for sex-specific diagnostic criteria and further research.
Sex differences may guide evaluation of secondary tricuspid regurgitation subtypes; leaves open need for sex-specific criteria and prospective validation.
In recent decades, a burgeoning interest in tricuspid regurgitation (TR) has been prompted by a heightened awareness of its prevalence and the advent of dedicated percutaneous treatment approaches. Despite considerable understanding of its intricate anatomy and response to varying pressure and loading conditions, the impact of biological sex remains a subject of investigation. While TR typically afflicts more women, significant differences in TR etiology and post-treatment outcomes have not been conclusively established. This narrative review seeks to consolidate the latest evidence concerning sex-related nuances in anatomy, pathophysiology, diagnosis, treatment, and prognosis of significant tricuspid regurgitation. Through synthesizing this information, we aim to provide a comprehensive understanding of how sex may influence the management and prognosis of this condition.
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Paiva et al. (2024) conducted a review in Tricuspid Regurgitation. Biological sex vs. Male vs Female was evaluated. Atrial secondary tricuspid regurgitation affects women more frequently, while ventricular secondary tricuspid regurgitation is more common in men, with women often presenting with more advanced disease.
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