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Examine the cellular mechanisms governing responses to mechanical stress, using endothelial cell biomechanics as a paradigm for cellular adaptation across biological systems.

February 1, 1993Circulation ResearchOpen Access

Mechanical stress mechanisms and the cell. An endothelial paradigm.

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Examine the cellular mechanisms governing responses to mechanical stress, using endothelial cell biomechanics as a paradigm for cellular adaptation across biological systems.
Reviewed literature on endothelial cell responses to biomechanical forces.
Evaluated cardiovascular physiological and pathological implications linked to cellular biomechanics and mechanical stress accommodation.
Endothelial biomechanical properties directly influence downstream physiological regulation and pathological disease states in the cardiovascular system.
Mechanosensitivity is an ubiquitous cellular characteristic, with non-endothelial cell types similarly possessing mechanisms to sense and adapt to environmental physical forces.

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Implication

Review highlights mechanical stress responses in endothelial cells, suggesting universal cellular adaptation principles govern cardiovascular physiology and pathology.

Cite This Study

Davies et al. (1993) studied this question.

synapsesocial.com/papers/6a18376bcf49e78c48b4ef67 https://doi.org/10.1161/01.res.72.2.239

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Implication

Review highlights mechanical stress responses in endothelial cells, suggesting universal cellular adaptation principles govern cardiovascular physiology and pathology.

Mechanical stress mechanisms and the cell. An endothelial paradigm.

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Discussion

Implication

Cite This Study

Mechanical stress mechanisms and the cell. An endothelial paradigm.

Key Points

Discussion

Implication

Cite This Study

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