Key result
Low baseline resting heart rate (<65 bpm) was associated with a higher risk of incident cardiovascular disease (HR 1.19) compared to a moderate baseline heart rate (65 to 80 bpm).
Why the study?
Whether heart rate change is associated with cardiovascular disease in the general population was unclear.
Is resting heart rate and its change associated with incident cardiovascular events in middle-aged and older Chinese adults?
Cohort (n=20,828)
Is resting heart rate and its change associated with incident cardiovascular events in middle-aged and older Chinese adults?
Effect estimate: HR 1.19 (95% CI 1.07-1.32)
In a middle-aged and older Chinese cohort, both a low resting heart rate (<65 bpm) and extreme changes in heart rate (continuous increase in high baseline or decrease in low baseline) were associated with an increased risk of incident cardiovascular disease.
Low resting heart rate may flag higher CVD risk but should not change practice; leaves open causality and generalizability in Chinese adults.
Whether heart rate change is associated with cardiovascular disease (CVD) in the general population is unclear. We conducted a prospective cohort study to assess the association of resting heart rate and its change with incident CVD in the middle-aged and older Chinese. Resting heart rate was measured during the baseline survey (September 2008 to June 2010) and the resurvey (2013). Incident CVD was followed up until December 31, 2016. Finally, a total of 20,828 participants were included in the analyses of baseline heart rate and 9132 participants were included in the analyses of heart rate change. The associations of baseline heart rate and heart rate change with incident CVD were assessed with multivariable Cox proportional hazards models. Compared with moderate baseline heart rate (65 to 80 bpm), low baseline heart rate (<65 bpm) was associated with higher risk of CVD (HR, 1.19; 95% CI, 1.07-1.32). Compared with stable heart rate (-5 to 15 bpm) in the moderate baseline heart rate group (65 to 80 bpm), an increase of heart rate (>15 bpm) in high baseline heart rate group (>80 bpm) (HR, 1.67; 95% CI, 1.02-2.71) or a decrease of heart rate (<-5 bpm) in low baseline heart rate group (<65 bpm) (HR, 2.48; 95% CI, 1.27-4.82) was associated with higher risk of CVD. In conclusion, low resting heart rate is associated with higher risk of CVD. Both continuous increase in high baseline heart rate and decrease in low baseline heart rate are associated with higher risk of CVD.
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Tian et al. (2019) conducted a cohort in Incident cardiovascular events (n=20,828). Low baseline resting heart rate (<65 bpm) vs. Moderate baseline resting heart rate (65 to 80 bpm) was evaluated on Incident cardiovascular disease (CVD) (HR 1.19, 95% CI 1.07-1.32). Low baseline resting heart rate (<65 bpm) was associated with a higher risk of incident cardiovascular disease (HR 1.19) compared to a moderate baseline heart rate (65 to 80 bpm).
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