Key result
In patients with Brugada syndrome, the presence of an SCN5A mutation was associated with a significantly higher incidence of spontaneous type 1 ECG pattern (71% vs 28%, p<0.001) and longer conduction intervals compared to those without the mutation.
Observational (n=46)
No
SCN5A mutation links to more spontaneous type 1 ECGs in Brugada syndrome; hypothesis-generating for refined risk stratification.
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Bockeriа et al. (2017) conducted an observational in Brugada syndrome (n=46). SCN5A mutation (Genotype-positive) vs. No SCN5A mutation (Genotype-negative) was evaluated on Spontaneous type 1 Brugada ECG pattern (p=<0.001). In patients with Brugada syndrome, the presence of an SCN5A mutation was associated with a significantly higher incidence of spontaneous type 1 ECG pattern (71% vs 28%, p<0.001) and longer conduction intervals compared to those without the mutation.
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