This review highlights the methodological challenges in assessing human endothelial function and concludes that mechanistic interpretations from animal models are generally applicable to human vasculature.
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Supports translation of animal endothelial findings to humans; leaves open need for direct mechanistic validation amid assessment challenges.
This brief review discusses the ways, if and when available, to examine endothelium-dependent changes diameter in human blood vessels. It stresses the problems in ensuring proper matching between arteries (and veins) from different human sources. It briefly considers the evidence in vitro supporting the role of endothelium-derived nitric oxide, hyperpolarizing factor and contracting factors (including metabolites of arachidonic acid and endothelin). It emphasizes the difficulty in extrapolating observations obtained in isolated arteries (and veins) to the intact human circulation. The overall conclusion is that the interpretations derived from animal work apply to the human vasculature.
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Paul M. Vanhoutte (1999) studied this question.
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