Key result
Open-loop systems analysis using baroreceptor isolation characterizes the static and dynamic properties of the neural and peripheral arcs of the arterial baroreflex system in rabbits and rats.
Quantitative understanding of the arterial baroreflex function through open-loop systems analysis in animal models provides foundational knowledge that could help develop new treatment strategies for conditions like drug-resistant hypertension.
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Hypothesis-generating for baroreflex-targeted hypertension therapies; leaves open translation to human trials.
The arterial baroreflex system is the most important negative feedback system for stabilizing arterial pressure (AP). This system serves as a key link between the autonomic nervous system and the cardiovascular system, and is thus essential for understanding the pathophysiology of cardiovascular diseases and accompanying autonomic abnormalities. This article focuses on an open-loop systems analysis using a baroreceptor isolation preparation to identify the characteristics of two principal subsystems of the arterial baroreflex system, namely, the neural arc from pressure input to efferent sympathetic nerve activity (SNA) and the peripheral arc from SNA to AP. Studies on the static and dynamic characteristics of the two arcs under normal physiological conditions and also under various interventions including diseased conditions are to be reviewed. Quantitative understanding of the arterial baroreflex function under diseased conditions would help develop new treatment strategies such as electrical activation of the carotid sinus baroreflex for drug-resistant hypertension.
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Kawada et al. (2015) conducted a review in Arterial baroreflex system physiology. Open-loop systems analysis was evaluated. Open-loop systems analysis using baroreceptor isolation characterizes the static and dynamic properties of the neural and peripheral arcs of the arterial baroreflex system in rabbits and rats.
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