Key result
Severe hemorrhage lowered the gain and offset of the neuromechanical arc and moved the operating point, whereas the mechanoneural arc remained unchanged.
Population
16 halothane-anesthetized rats with isolated carotid sinuses and bilaterally cut vagi and aortic depressor…
Comparison
Sequential alteration of carotid sinus pressure… vs Baseline states vs severe hemorrhage
Design
Preclinical
Authors
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Validates equilibrium diagram for baroreflex operating point in rats; leaves open translation to human physiology or practice.
An analytic framework using an equilibrium diagram of mechanoneural and neuromechanical arcs accurately determines the operating point of the sympathetic baroreflex system.
Sato et al. (1999) studied this question. Carotid sinus pressure alteration and hemorrhage vs. Baseline states was evaluated on Operating point of the arterial baroreflex (intersection of mechanoneural and neuromechanical arcs). Severe hemorrhage lowered the gain and offset of the neuromechanical arc and moved the operating point, whereas the mechanoneural arc remained unchanged.