Key result
Sinoaortic baroreceptor denervated rats had increased spectral power (+680%) of arterial pressure in the low frequency range and reduced power (-19%) in the mid-frequency range compared to intact rats.
Population
Conscious sinoaortic baroreceptor denervated (SAD) rats (n=10) and baroreceptor-intact rats (n=8)
Comparison
Linear modelling analysis of baroreflex control… vs Baroreceptor-intact rats
Design
Preclinical
Authors
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Rat data extend linear feedback modeling of sympathetic AP control; leaves open translation to human baroreflex physiology.
A linear feedback model demonstrates that the sympathetic component of the arterial baroreceptor reflex corrects slow hemodynamic perturbations at the cost of increasing transients at higher frequencies, while remaining fundamentally stable.
Chapuis et al. (2004) studied Arterial pressure variability (n=18). Sinoaortic baroreceptor denervation vs. Baroreceptor-intact rats was evaluated on Spectral power of arterial pressure in low frequency (LF) and mid-frequency (MF) ranges. Sinoaortic baroreceptor denervated rats had increased spectral power (+680%) of arterial pressure in the low frequency range and reduced power (-19%) in the mid-frequency range compared to intact rats.
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