Key result
Transfer gain was significantly lower in rats with aortic baroreceptor denervation (1.48 +/- 0.22 NU/mmHg) compared to baroreceptor-intact controls (2.39 +/- 0.13 NU/mmHg, P=0.0049).
Population
Conscious rats, either baroreceptor-intact or with partial denervation of baroreflex afferents
Comparison
Transfer function method relating… vs Vasoactive drug injection technique
Design
Preclinical
Follow-up
1-h periods of spontaneous activity
Authors
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May index sympathetic BRS via RSNA-AP transfer function in rats; leaves open human validation and clinical utility.
Absolute Event Rate: 1.48% vs 2.39%
p-value: p=0.0049
The transfer function method provides a continuous, functionally relevant index of sympathetic baroreflex sensitivity in rats.
Kanbar et al. (2007) studied Sympathetic baroreflex sensitivity (n=21). Aortic baroreceptor denervation vs. Baroreceptor-intact (control) was evaluated on Transfer gain (normalized units/mmHg) (p=0.0049). Transfer gain was significantly lower in rats with aortic baroreceptor denervation (1.48 +/- 0.22 NU/mmHg) compared to baroreceptor-intact controls (2.39 +/- 0.13 NU/mmHg, P=0.0049).
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