What does this research mean for the field?

Simultaneous measurement of fractional flow reserve (FFR) and coronary flow reserve (CFR) using a single pressure-temperature sensor-tipped guide wire via coronary thermodilution is feasible and correlates well with Doppler-derived measurements. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The study aims to evaluate the feasibility of measuring fractional flow reserve (FFR) and coronary flow reserve (CFR) simultaneously using a single guide wire.

May 28, 2002CirculationOpen Access

Coronary Thermodilution to Assess Flow Reserve

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Why the study?

Does coronary flow reserve measured by thermodilution correlate with Doppler-derived coronary flow reserve in human coronary arteries?

Key Points

The study aims to evaluate the feasibility of measuring fractional flow reserve (FFR) and coronary flow reserve (CFR) simultaneously using a single guide wire.
Conducted in 50 patients with 103 coronary arteries, using pressure-temperature sensor-tipped and Doppler guide wires.
Measured thermodilution curves using saline as an indicator to calculate CFR(thermo) at baseline and during hyperemia.
Compared CFR(thermo) with Doppler-derived CFR(Doppl) based on velocity measurements.
CFR(thermo) showed a correlation with CFR(Doppl) (CFR(thermo)=0.84 CFR(Doppl)+0.17; r=0.80; P<0.001).
Adequate thermodilution curves were obtained in 87% of arteries, compared to 91% for Doppler CFR and 100% for FFR.
Individual differences of over 20% between CFR(thermo) and CFR(Doppl) were observed in 25% of the arteries.

Structured PICO

Does coronary flow reserve measured by thermodilution correlate with Doppler-derived coronary flow reserve in human coronary arteries?

Population

50 patients (103 coronary arteries) including both normal vessels and a wide range of stenotic vessels

Intervention

Measurement of coronary flow reserve (CFR) by thermodilution using a pressure-temperature sensor-tipped 0.014-inch floppy guide wire (3 mL room temperature saline hand-injection at baseline and intravenous adenosine-induced maximum hyperemia)

Comparator

Simultaneously measured Doppler CFR using a 0.014-inch Doppler guide wire

Outcome

Correlation between CFR by thermodilution and Doppler CFR, and feasibility of obtaining adequate thermodilution curvessurrogate

Simultaneous measurement of FFR and CFR using a single pressure-temperature sensor-tipped guide wire via thermodilution is feasible and correlates well with Doppler CFR.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May facilitate combined FFR/CFR assessment with one wire; extends correlation data but should not yet change practice.

Cite This Study

Pijls et al. (2002) studied this question.

synapsesocial.com/papers/6a1886c61ca866914fc9bf33 https://doi.org/10.1161/01.cir.0000017199.09457.3d

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Coronary Thermodilution to Assess Flow Reserve

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Coronary Thermodilution to Assess Flow Reserve

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider