Key result
Young adult offspring of hypertensive parents exhibited higher baseline blood pressure and BMI, and a greater sympathetic-to-parasympathetic ratio after a carbohydrate load compared to controls.
Why the study?
Do young adult offspring of hypertensive parents exhibit altered anthropometric, hemodynamic, and autonomic variables at baseline and in response to oral carbohydrates compared to offspring of normotensive parents?
Observational (n=200)
Do young adult offspring of hypertensive parents exhibit altered anthropometric, hemodynamic, and autonomic variables at baseline and in response to oral carbohydrates compared to offspring of normotensive parents?
Young adult offspring of hypertensive parents demonstrate early anthropometric and hemodynamic abnormalities, along with exaggerated sympathetic autonomic responses to carbohydrate loading, prior to the onset of clinical hypertension.
Early BP/autonomic differences in offspring of hypertensives merit longitudinal study; leaves open predictive value and any preventive role.
Young adult offspring of hypertensive parents (pHTN⊕) are a good model for assessing abnormalities of anthropometric, cardiometabolic, and autonomic variables prior to clinical hypertension. The objectives of this study were to determine whether these variables and autonomic responses to oral carbohydrates were altered in offspring of pHTN⊕. Two hundred consecutive patients, including 100 pHTN⊕, were evaluated, with 29 patients, including 14 pHTN⊕, given a 70-gram carbohydrate load. The pHTN⊕ group had higher blood pressure, pulse pressure, abdominal circumference (AC), weight, body mass index, and basal metabolic rate than offspring of normotensive parents (pHTN∅). At baseline, the low-frequency (LF, sympathetic) to high-frequency (HF, parasympathetic) ratio, assessed by spectral analysis of heart rate variability, was similar in both groups. After the carbohydrate load, the LF/HF ratio was greater in offspring of pHTN⊕. pHTN⊕ individuals have abnormalities of anthropometric and hemodynamic variables at baseline and autonomic responses to oral carbohydrates before developing hypertension.
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Motta et al. (2016) conducted an observational in Offspring of hypertensive parents (n=200). 70-gram carbohydrate load vs. Offspring of normotensive parents was evaluated on Anthropometric, hemodynamic, and autonomic variables (LF/HF ratio). Young adult offspring of hypertensive parents exhibited higher baseline blood pressure and BMI, and a greater sympathetic-to-parasympathetic ratio after a carbohydrate load compared to controls.
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