Key result
Family history of hypertension linked to ~5 mm Hg higher systolic blood pressure in normotensive offspring.
Why the study?
Do normotensive offspring of hypertensive parents have altered arterial characteristics and blood pressure compared to offspring of normotensive parents?
Cross-Sectional (n=233)
Yes
Do normotensive offspring of hypertensive parents have altered arterial characteristics and blood pressure compared to offspring of normotensive parents?
Alterations in arterial function in normotensive subjects with a family history of hypertension appear to be driven primarily by increased blood pressure and age-related hemodynamic changes rather than intrinsic large-artery stiffness.
Answers are grounded in this paper and cite their sources.
Supports vigilant BP monitoring in normotensive offspring of hypertensives; leaves open whether family history confers intrinsic arterial changes independent of BP.
BACKGROUND: In this study we compared the arterial characteristics and blood pressure (BP) of normotensive offspring of two normotensive parents (OFF/NT) and normotensive offspring who had at least one hypertensive parent (OFF/HT). METHODS: A total of 174 OFF/HT (17 to 40 years of age) and 59 OFF/NT (16 to 34 years) were recruited in Cracow, Poland (n = 138) and Pilsen, Czech Republic (n = 95). Peripheral pulse pressure (PPp) was determined from conventional and 24-h ambulatory BP. A SphygmoCor device was used to measure the central (CAIx) and peripheral (PAIx) systolic augmentation indexes, central pulse pressure (PPc), and the aortic pulse wave velocity (PWV). In multivariate analyses family clusters and significant covariates were accounted for. RESULTS: The OFF/HT had higher (.14 < P < .0007) conventional BP and PPp on conventional BP measurement (121/75 v 114/71 mm Hg and 46 v 42 mm Hg) as well as on 24-h ambulatory monitoring (118/70 v 114/67 mm Hg and 48 v 47 mm Hg). OFF/HT, compared with OFF/NT, also had higher (.05 < P < .0008) PPc (28 v 26 mm Hg), PAIx (54.7% v 44.9%), CAIx (108.8% v 99.8%), and PWV (7.4 v 6.6 m/sec). However, complex adjustment including mean arterial pressure and age removed the differences between the offspring in the PAIx, CAIx, and PWV. CONCLUSIONS: Large-artery properties are altered in OFF/HT compared with OFF/NT. The findings from this cross-sectional study suggest that the alterations in arterial function in subjects with a family history of hypertension are determined mainly by an increased BP and age-related hemodynamic changes.
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Kucerová et al. (2006) conducted a cross-sectional in Normotensive with or without family history of hypertension (n=233). Family history of hypertension vs. Two normotensive parents was evaluated on Adjusted conventional systolic blood pressure (p=0.009). Normotensive offspring with a family history of hypertension had significantly higher adjusted conventional systolic blood pressure compared to those with normotensive parents (120 vs 115 mm Hg).
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