January 1, 1992Thrombosis and Haemostasis
D-Dimer and Thrombin-Antithrombin III Complexes in Patients with Clinically Suspected Pulmonary Embolism
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Why the study?
Does the measurement of D-dimer and TAT complexes accurately rule out pulmonary embolism in patients with clinically suspected PE?
Population
156 consecutive patients with clinically suspected pulmonary embolism (PE)
Comparison
Measurement of D-dimer and thrombin-antithrombin… vs Reference standard of ventilation/perfusion lung…
Design
Cohort
Follow-up
3 months (for PE-unlikely patients)
Authors
Discussion
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Implication
May aid ruling out PE in suspected cases; leaves open prospective validation before practice change.
Structured PICO
Does the measurement of D-dimer and TAT complexes accurately rule out pulmonary embolism in patients with clinically suspected PE?
P
Population
156 consecutive patients with clinically suspected pulmonary embolism (PE)
I
Intervention
Measurement of D-dimer and thrombin-antithrombin (TAT) complexes
C
Comparator
Reference standard of ventilation/perfusion (V/Q) lung scanning, bilateral impedance plethysmography (IPG), and/or pulmonary angiography
O
Outcome
Diagnostic accuracy (sensitivity, specificity, positive predictive value, and negative predictive value) of D-dimer and TAT complex assays for pulmonary embolismsurrogate
D-dimer levels <300 ng/ml and TAT complexes <3.5 μg/ml have a high negative predictive value, making pulmonary embolism highly unlikely in these patients.
Cite This Study
Demers et al. (1992) studied this question.
Topics
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