Key result
Left ventricular hypertrabeculation requires multiparametric clinical evaluation beyond morphology alone to guide management.
Why the study?
Despite numerous diagnostic criteria and phenocopies, no specific consensus identifies a flowchart for managing patients with suspected left ventricular hypertrabeculation.
This review outlines the diagnostic criteria, clinical manifestations, and management strategies for left ventricular hypertrabeculation, emphasizing the need to differentiate true cardiomyopathy from benign phenotypic variants.
May warrant syndrome-driven evaluation in LV hypertrabeculation; leaves open prospective validation of multiparametric criteria.
Left ventricular hypertrabeculation is one of the most debated conditions in modern cardiology. Many studies have tried to characterise this disease by addressing the various clinical risks and diagnostic tools, but its very nosological existence is currently being challenged. The latest ESC guidelines on cardiomyopathies state that it should be addressed as a morphologic trait rather than an intrinsic disease of the cardiac muscle. Despite the huge number of diagnostic criteria and possible phenocopies, no specific consensus identifies a specific flowchart regarding the management of patients with suspected hypertrabeculation. This review aims to provide a clinical approach for patients with a phenotypical appearance of excessive trabeculation.
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Alfieri et al. (2025) conducted a review in Left ventricular hypertrabeculation. Management of left ventricular hypertrabeculation was evaluated. Left ventricular hypertrabeculation requires a tailored, multiparametric clinical approach based on the presence of an effective clinical syndrome rather than solely a morphological pattern.
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