Why the study?
Does chronic ventricular tachycardia alter myosin heavy chain synthesis in a rabbit model of heart failure?
Population
Rabbit model of heart failure
Comparison
Chronic ventricular tachycardia vs Control rabbits
Design
Preclinical
Follow-up
3 weeks
Authors
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Accelerated MHC degradation may offset synthesis in chronic VT; leaves open hypertrophic mechanisms in animal HF models.
Does chronic ventricular tachycardia alter myosin heavy chain synthesis in a rabbit model of heart failure?
In a rabbit model of chronic VT-induced heart failure, increased myosin heavy chain synthesis without a change in total content suggests that accelerated protein degradation prevents myocardial hypertrophy despite increased wall stress.
Eble et al. (1997) studied this question.
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