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June 1, 2013Nephron Clinical Practice

Hypertriglyceridemic Waist is Associated with Increased Carotid Atherosclerosis in Chronic Kidney Disease Patients

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Why the study?

Is the hypertriglyceridemic waist phenotype associated with increased carotid atherosclerosis in patients with chronic kidney disease?

Population

785 prevalent chronic kidney disease patients, 416 males, aged 44.6 years, glomerular filtration rate 52.5…

Comparison

Hypertriglyceridemic waist phenotype vs Normal waist and triglycerides and an…

Design

Cross-sectional

Key result

The hypertriglyceridemic waist phenotype, present in 13.8% of patients, was associated with the highest carotid artery intima-media thickness in chronic kidney disease.

Authors

XZXing‐wei ZheYBYunkai BaiYCYing Cheng

Discussion

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Overview

Hypertriglyceridemic waist may flag higher atherosclerosis risk in CKD; hypothesis-generating pending prospective validation.

Study Design

Type

Cross-Sectional (n=785)

Structured PICO

Is the hypertriglyceridemic waist phenotype associated with increased carotid atherosclerosis in patients with chronic kidney disease?

P
Population
785 prevalent chronic kidney disease (CKD) patients, 416 males, aged 44.6 years (21.7-69.4), glomerular filtration rate 52.5 ml/min/1.73 m2 (5.3-119.4)
I
Intervention
Hypertriglyceridemic waist phenotype (waist circumference >90 cm in men or >85 cm in women and triglycerides ≥2 mmol/l)
C
Comparator
Normal waist and triglycerides (waist circumference ≤90 cm in men or ≤85 cm in women and triglycerides <2 mmol/l) and an intermediate group
O
Outcome
Carotid artery intima-media thickness (IMT)surrogate

The hypertriglyceridemic waist phenotype is associated with worse carotid atherosclerosis in CKD patients, suggesting its utility as a simple marker for predicting CVD risk.

Cite This Study

Zhe et al. (2013) conducted a cross-sectional in Chronic kidney disease (n=785). Hypertriglyceridemic waist phenotype vs. Normal waist circumference and triglycerides was evaluated on Carotid artery intima-media thickness (IMT). The hypertriglyceridemic waist phenotype, present in 13.8% of patients, was associated with the highest carotid artery intima-media thickness in chronic kidney disease.

synapsesocial.com/papers/6a18bcafd36da06b0a91a089https://doi.org/10.1159/000351042
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Association of Hypertriglyceridemic Waist Phenotype with Chronic Kidney Disease and Its Sex Difference: A Cross-Sectional Study in an Urban Chinese Elderly Population2016 · 18 citations
  2. 2Hypertriglyceridemic Waist: A Simple Marker of High‐Risk Atherosclerosis Features Associated With Excess Visceral Adiposity/Ectopic Fat2018 · 37 citations
  3. 3The hypertriglyceridemic-waist phenotype and the risk of coronary artery disease: results from the EPIC-Norfolk Prospective Population Study2010 · 185 citations
  4. 4Hypertriglyceridemic Waist Phenotype Predicts Increased Visceral Fat in Subjects With Type 2 Diabetes2009 · 168 citations
  5. 5#331 Vascular and lipid profile interplays in pediatric CKD patients2024