Key result
Higher young-adult nonhypertensive SBP is linked to ~50% higher odds of elevated CIMT per SD.
Why the study?
To examine the association of blood pressure levels with coronary artery calcium and CIMT in adults with maintained blood pressure below the hypertension range.
Does higher cumulative blood pressure within the nonhypertensive range increase the risk of subclinical atherosclerosis (CAC and CIMT) in young adults?
Population
1233 adults with untreated BP <130/80 mm Hg from 4 US cities
Comparison
Cumulative BP measures across early adulthood
Design
Post hoc analysis of a prospective observational cohort study
Follow-up
20 years
Authors
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May warrant attention to cumulative systolic BP in nonhypertensive young adults; extends prior observational data on subclinical atherosclerosis.
Cohort (n=1,233)
Yes
Does higher cumulative blood pressure within the nonhypertensive range increase the risk of subclinical atherosclerosis (CAC and CIMT) in young adults?
Odds Ratio: 1.5 (95% CI 1.19–1.88)
p-value: p=<0.001
Long-term exposure to higher systolic blood pressure and pulse pressure during early adulthood, even when maintained below 130/80 mm Hg, is independently associated with increased carotid intima-media thickness in middle age.
Masrouri et al. (2023) conducted a cohort in Nonhypertensive blood pressure (<130/80 mm Hg) (n=1,233). Cumulative systolic blood pressure vs. Lower cumulative systolic blood pressure (per 1-SD increase) was evaluated on Maximal carotid intima-media thickness (CIMT) >1.01 mm (OR 1.50, 95% CI 1.19-1.88, p=<0.001). Higher long-term cumulative systolic blood pressure across early adulthood within the nonhypertensive range was associated with a 50% higher odds of maximal CIMT >1.01 mm per 1-SD increase (OR 1.50).
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