Key result
Angiotensin II receptor blockers demonstrate comparable antihypertensive efficacies within the class, though longer-acting agents may be more effective at providing 24-hour blood pressure control.
Why the study?
Do different Angiotensin II Receptor Blockers have varying efficacy in blood pressure control and heart failure management?
Population
Patients with mild to moderate hypertension and patients with heart failure
Comparison
Angiotensin II Receptor Blockers including… vs Other ARBs or ACE inhibitors
Design
Review
Authors
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Longer-acting ARBs may aid 24-hour BP control; leaves open whether this affects heart failure outcomes versus established agents.
Do different Angiotensin II Receptor Blockers have varying efficacy in blood pressure control and heart failure management?
While newer ARBs offer longer half-lives for better 24-hour blood pressure control, losartan and valsartan have established evidence for long-term morbidity and mortality benefits in heart failure.
Barreras et al. (2003) conducted a review in Hypertension and heart failure. Angiotensin II Receptor Blockers (ARBs) vs. ACE inhibitors was evaluated. Angiotensin II receptor blockers demonstrate comparable antihypertensive efficacies within the class, though longer-acting agents may be more effective at providing 24-hour blood pressure control.
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