Metastatic Intimal Sarcoma of the Pulmonary Artery Sensitive to Carboplatin-Vinorelbine Chemotherapy: Case Report and Literature Review

Figures

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  Fig. 1.. Pathological aspects of the pulmonary metastasis from the pulmonary artery intimal sarcoma. a Hematoxylin-eosin-saffron (HES) staining of the pulmonary biopsy showing a poorly differentiated necrotic lesion. ×10. b The spindle tumour cells are severely atypical with numerous mitoses. HES. ×40. c Immunohistochemistry staining showing expression of MDM2 by tumour cells. d FISH analysis showing numerous red signals in tumour cells revealing an amplification of the 12q15 region, which contains the MDM2 gene.

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  Fig. 2.. Radiological response to carboplatin-vinorelbine chemotherapy. Chest CT scans during 4 successive periods of treatment with carboplatin-vinorelbine. a–d January 2017, before the 1st cycle. Four lesions are shown (red arrows): 2 intraparenchymal lesions (a, b), 1 lesion in contact with the second rib (c), and 1 lesion of the right posterior inframediastinal space (d). e–h April 2017, after 3 cycles. Regression of all 4 lesions. i–l June 2017, after 6 cycles. Continued regression of all 4 lesions. m–p October 2017, after 9 cycles. Stability of the intraparenchymal lesions (m, n), but progression of the inframediastinal lesion (p) and the lesion in contact with the second rib (o).