Key result
The combination of salivary lactate and 8-isoprostaglandin F2α successfully discriminated between acute heart failure admission and discharge with an AUC of 0.871.
Why the study?
Heart failure activates multiple compensatory mechanisms and neurohormonal systems, prompting the hypothesis that monitoring a panel of non-invasive salivary biomarkers could help predict HF evolution.
Do salivary lactate and 8-isoprostaglandin F2α correlate with NT-proBNP and clinical improvement in patients hospitalized for acute heart failure?
Observational (n=44)
No
Do salivary lactate and 8-isoprostaglandin F2α correlate with NT-proBNP and clinical improvement in patients hospitalized for acute heart failure?
Effect estimate: AUC 0.871 (95% CI 0.761-0.951)
p-value: p=<0.001
Salivary lactate and 8-isoprostaglandin F2α show promise as non-invasive biomarkers for monitoring clinical status and improvement in patients with acute heart failure.
May support non-invasive acute HF monitoring; hypothesis-generating and requires prospective validation before practice change.
Heart failure (HF) is a cardiovascular disease affecting about 26 million people worldwide costing about $100 billons per year. HF activates several compensatory mechanisms and neurohormonal systems, so we hypothesized that the concomitant monitoring of a panel of potential biomarkers related to such conditions might help predicting HF evolution. Saliva analysis by point-of-care devices is expected to become an innovative and powerful monitoring approach since the chemical composition of saliva mirrors that of blood. The aims of this study were (i) to develop an innovative procedure combining MEPS with UHPLC-MS/MS for the simultaneous determination of 8-isoprostaglandin F 2α and cortisol in saliva and (ii) to monitor lactate, uric acid, TNF-α, cortisol, α-amylase and 8-isoprostaglandin F 2α concentrations in stimulated saliva samples collected from 44 HF patients during their hospitalisation due to acute HF. Limit of detection of 10 pg/mL, satisfactory recovery (95–110%), and good intra- and inter-day precisions (RSD ≤ 10%) were obtained for 8-isoprostaglandin F 2α and cortisol. Salivary lactate and 8-isoprostaglandin F 2α were strongly correlated with NT-proBNP. Most patients (about 70%) showed a significant decrease (a factor of 3 at least) of both lactate and 8-isoprostaglandin F 2α levels at discharge, suggesting a relationship between salivary levels and improved clinical conditions during hospitalization.
No takes yet. Share an insight, caveat, or question.
Ghimenti et al. (2020) conducted an observational in Acute Heart Failure (n=44). Salivary biomarker monitoring (lactate and 8-isoPGF2α) vs. Hospital admission (acute phase) was evaluated on Discrimination between hospital admission and discharge using combined biomarkers (AUC 0.871, 95% CI 0.761-0.951, p=<0.001). The combination of salivary lactate and 8-isoprostaglandin F2α successfully discriminated between acute heart failure admission and discharge with an AUC of 0.871.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: