Key result
Female TG(mRen2)27 rats demonstrated relative protection from autonomic dysfunction, decreased heart rate variability, and end-organ damage compared with male rats.
Why the study?
Does female sex protect against autonomic dysfunction and end-organ damage in the Ren2 rat model of hypertension compared to male sex?
Does female sex protect against autonomic dysfunction and end-organ damage in the Ren2 rat model of hypertension compared to male sex?
Female Ren2 rats demonstrate relative protection from autonomic dysfunction and end-organ damage associated with elevated blood pressure compared to males.
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Hypothesis-generating for sex differences in hypertensive autonomic dysfunction; requires human studies before any clinical consideration.
Johnson et al. (2011) studied Hypertension. Female sex vs. Male sex was evaluated on Baroreflex sensitivity, heart rate variability, and end-organ damage. Female TG(mRen2)27 rats demonstrated relative protection from autonomic dysfunction, decreased heart rate variability, and end-organ damage compared with male rats.
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