Key result
Children with a history of Kawasaki disease showed no significant differences in left atrial reservoir function, including peak left atrial longitudinal strain, compared to normal controls at a mean 5-year follow-up.
Why the study?
Does a history of Kawasaki disease impair long-term left atrial reservoir function and left ventricular diastolic function in children?
Case-Control (n=44)
Single-blind
No
Does a history of Kawasaki disease impair long-term left atrial reservoir function and left ventricular diastolic function in children?
Left ventricular diastolic function, as assessed by left atrial reservoir function parameters, appears to be preserved at long-term follow-up in children with a history of Kawasaki disease.
Answers are grounded in this paper and cite their sources.
Supports preserved LA reservoir function at 5-year follow-up after Kawasaki disease; leaves open larger prospective validation of long-term diastolic outcomes.
BACKGROUND: Decreased left atrial (LA) reservoir function is reported to be associated with elevated left ventricular (LV) end diastolic pressure and LV diastolic dysfunction. Echocardiographic parameters that reflect LA reservoir function include LA total emptying fraction [(maximum LA volume - minimum LA volume) / maximum LA volume], peak LA longitudinal strain (PLALS) at systole, and LA stiffness index (E/E´/PLALS). We aimed to investigate the long-term outcomes of LV diastolic function in children with a history of Kawasaki disease (KD) (KDHx group) by assessing LA reservoir function. METHODS: Retrospectively, echocardiograms performed at a mean follow-up period of 5 years after the acute phase of KD in 24 children in the KDHx group were compared to those from 20 normal control subjects. LA total emptying fraction, PLALS, LA stiffness index, LV peak longitudinal systolic strain (ε), and strain rate (SR) were evaluated with conventional echocardiographic parameters. RESULTS: The mean age at long term follow-up echocardiography in children in the KDHx group was 6.8 years. Five children (20.8%) had coronary artery lesions (CALs) in the acute stage of KD. No children showed CALs at a mean follow-up period of 5 years after the acute phase of KD. There were no significant differences in the conventional echocardiographic parameters and in LA total emptying fraction, PLALS, LA stiffness index, LV peak longitudinal systolic ε, and SR, between the children in the KDHx and control group. CONCLUSION: LV diastolic function assessed by LA reservoir function parameters at long-term follow-up in children in the KDHx group appears to be favorable.
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Kang et al. (2018) conducted a case-control in Kawasaki disease (n=44). History of Kawasaki disease vs. Normal controls was evaluated on Peak left atrial longitudinal strain (PLALS) (p=0.144). Children with a history of Kawasaki disease showed no significant differences in left atrial reservoir function, including peak left atrial longitudinal strain, compared to normal controls at a mean 5-year follow-up.
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