Key result
Microvascular dysfunction may compromise FFR accuracy for assessing stenosis severity, particularly in post-menopausal women.
Design
Review
Authors
Loading...
Caution advised interpreting FFR in post-menopausal women; leaves open sex-specific validation of physiologic indices.
This review summarizes the physiological basis, advantages, and limitations of fractional flow reserve (FFR), highlighting that microvascular dysfunction can impair hyperemic responses and lead to false normal FFR values, which may disproportionately affect women.
Crystal et al. (2015) conducted a review in Coronary artery disease. Fractional Flow Reserve (FFR) was evaluated. Fractional flow reserve provides a physiological assessment of coronary stenosis severity, but its accuracy may be compromised by microvascular dysfunction, particularly in post-menopausal women.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: