An international perspective on heart failure and left ventricular systolic dysfunction complicating myocardial infarction: the VALIANT registry
Key result
Heart failure and/or left ventricular systolic dysfunction complicating acute myocardial infarction was associated with higher in-hospital mortality (13.0% vs 2.3%; HR 4.12, 95% CI 3.08-5.56).
Why the study?
What is the incidence and impact on in-hospital mortality of heart failure and/or left ventricular systolic dysfunction complicating acute myocardial infarction?
Population
5573 consecutive patients with acute myocardial infarction at 84 hospitals in nine countries from 1999 to…
Design
Cohort
Follow-up
in-hospital
Authors
Discussion
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Member takes
Implication
Raises alert for in-hospital mortality with HF/LVSD in acute MI; confirms association in cohort data but leaves causal impact open.
Study Design
Type
Observational (n=5,566)
Multicenter
Yes
Structured PICO
What is the incidence and impact on in-hospital mortality of heart failure and/or left ventricular systolic dysfunction complicating acute myocardial infarction?
P
Population
5573 consecutive patients with acute myocardial infarction (MI) at 84 hospitals in nine countries from 1999 to 2001.
C
Comparator
Patients without heart failure and/or without left ventricular systolic dysfunction
O
Outcome
In-hospital mortalityhard clinical
Main Result
Effect estimate: HR 4.12 (95% CI 3.08-5.56)
Absolute Event Rate: 13% vs 2.3%
Heart failure and/or left ventricular systolic dysfunction is common (42%) in acute MI patients and is associated with a significantly increased risk of in-hospital mortality (HR 4.12).
Cite This Study
Eric J. Velazquez (2004) conducted an observational in Acute myocardial infarction (n=5,566). Heart failure and/or left ventricular systolic dysfunction vs. No heart failure and/or left ventricular systolic dysfunction was evaluated on In-hospital mortality (HR 4.12, 95% CI 3.08-5.56). Heart failure and/or left ventricular systolic dysfunction complicating acute myocardial infarction was associated with higher in-hospital mortality (13.0% vs 2.3%; HR 4.12, 95% CI 3.08-5.56).