What question did this study set out to answer?

To review the evolving role of reactive oxygen species in cancer etiopathogenesis and summarize emerging therapeutic strategies that modulate oxidative balance to induce tumor cell death.

October 18, 2023Pathology & Oncology ResearchOpen Access

Recent advances and future directions in etiopathogenesis and mechanisms of reactive oxygen species in cancer treatment

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To review the evolving role of reactive oxygen species in cancer etiopathogenesis and summarize emerging therapeutic strategies that modulate oxidative balance to induce tumor cell death.
Synthesized recent literature examining genomic and epigenetic regulation of reactive oxygen species (ROS) in oncogenesis.
Evaluated molecular connections between ROS and distinct cell death pathways, including apoptosis, ferroptosis, necroptosis, and autophagy.
Assessed preclinical and clinical interventions modulating ROS via nanomedicine, nutraceuticals, metabolic inhibitors, and immunotherapies.
Low to moderate levels of ROS function as signal transducers that stimulate cancer proliferation, angiogenesis, and invasion, whereas excessive levels trigger lethal damage to nucleic acids, lipids, and organelles.
Therapeutic disruption of oxidative stress balance actively engages regulated cell death mechanisms, particularly showing complex crosstalk with ferroptosis and epigenetic modifications.
Multiple targeting strategies, including biomarker-driven therapies, immune modulators, and nanoparticle delivery platforms, demonstrate promising in vitro and in vivo efficacy by selectively shifting ROS concentrations.

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Implication

Review outlines reactive oxygen species mechanisms in cancer cell death, indicating novel therapeutic targets across nanomedicine and immunotherapy.

Cite This Study

Verma et al. (2023) studied this question.

synapsesocial.com/papers/6a192156a0353395e957e58b https://doi.org/10.3389/pore.2023.1611415

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Implication

Review outlines reactive oxygen species mechanisms in cancer cell death, indicating novel therapeutic targets across nanomedicine and immunotherapy.

Recent advances and future directions in etiopathogenesis and mechanisms of reactive oxygen species in cancer treatment

Key Points

Discussion

Implication

Cite This Study

Recent advances and future directions in etiopathogenesis and mechanisms of reactive oxygen species in cancer treatment

Key Points

Discussion

Implication

Cite This Study

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