Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
May 29, 2026Drug Healthcare and Patient SafetyOpen Access

Metoclopramide and Risk of Pheochromocytoma Crisis: A Causality Assessment Using Literature and VigiBase Data

View Full Paper
Ask AI
Bookmark
Share

Authors

MBMerhawi BahtaADAbraham DawitMOMillion Okubazghi

Discussion

Loading...

Member takes

Overview

Descriptive analysis evaluates the causal link between metoclopramide and pheochromocytoma crisis, suggesting a need for caution.

Key Points

  • This research investigates the causal link between metoclopramide use and pheochromocytoma crisis, aiming for a rigorous assessment.
  • Descriptive analysis of data from literature and WHO VigiBase pharmacovigilance database conducted on February 13, 2025.
  • Causality assessment at the individual level using the Naranjo Scale for case reports and at the population level using the Austin Bradford-Hill framework.
  • A total of 62 de-duplicated cases analyzed from VigiBase and literature.
  • Of 62 cases, almost all were serious, and 12 resulted in fatalities.
  • Naranjo assessment classified 18 cases as 13 'probable' and 5 'possible'.
  • Population-level assessment confirmed a strong causal relationship across all nine Bradford-Hill criteria.

Cite This Study

Bahta et al. (2026) studied this question.

synapsesocial.com/papers/6a192cd5fab5b468c4415a56https://doi.org/10.2147/dhps.s593970
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 15142 Pheochromocytoma In The ICU- Hiding In Plain Sight2024 · 1 citations
  2. 2The effect of metoclopramide on QT dynamicity: double‐blind, placebo‐controlled, cross‐over study in healthy male volunteers2003 · 51 citations
  3. 3Metoclopramide-Induced Neuroleptic Malignant Syndrome: A Review Study2020 · 4 citations
  4. 4Case Report: Methylprednisolone-induced pheochromocytoma crisis resulting in cardiac arrest2026
  5. 5P050 PITFALLS IN ESTABLISHING THE DIAGNOSIS OF PHEOCHROMOCYTOMA ILLUSTRATED BY THREE CASE REPORTS2024