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May 29, 2026Journal of Clinical Oncology

Clinical outcomes in TP53 -mutated clonal hematopoiesis: Single-center retrospective study.

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Authors

JHJacob Edward HersteinThe University of Texas Health Science Center at HoustonMMManuel MarounThe University of Texas MD Anderson Cancer CenterGMGuillermo Montalban-BravoThe University of Texas MD Anderson Cancer Center

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Implication

Retrospective study evaluates clinical outcomes in TP53-mutated clonal hematopoiesis, highlighting comorbidities and risk assessment challenges.

Key Points

  • The study aims to characterize clinical outcomes of patients with TP53-mutated clonal hematopoiesis.
  • Retrospective evaluation of patients with identified pathogenic TP53 mutations.
  • Inclusion of patients with clonal hematopoiesis of indeterminate potential and clonal cytopenia of undetermined significance.
  • Follow-up median time of 60.1 months.
  • Median overall survival from clonal hematopoiesis detection was 67.5 months (95% CI 59.0-NE).
  • 24% of patients progressed to myeloid neoplasms, primarily myelodysplastic syndromes (80%) and acute myeloid leukemia (20%).
  • No differences in transformation rates were associated with TP53 variant allele frequency.

Cite This Study

Herstein et al. (2026) studied this question.

synapsesocial.com/papers/6a192d2dfab5b468c4415fe5https://doi.org/10.1200/jco.2026.44.16_suppl.6594
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reduced overall survival in TP53-mutated ccus is driven by prior cytotoxic exposure and cytopenia rather than leukemic progression2025
  2. 2Genomic evolution of patients with myeloid neoplasms and known antecedent clonal hematopoiesis.2024 · 1 citations
  3. 3Clinical outcomes of TP53 -mutated myeloid neoplasms after allogeneic hematopoietic cell transplantation: A Canadian multicenter propensity score–matched analysis.2026
  4. 4Real world experience of patient outcomes in a dedicated clonal hematopoiesis hematology clinic2025 · 1 citations
  5. 5Real-world experience of cancer patients with clonal hematopoiesis in an urban county hospital system.2026